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The definition of alpha-2 adrenergic receptors

A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-proteins. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of adrenergic agonists, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of neurotransmitter release.

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