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Definition: bovine leukocyte adhesion deficiency

An autosomal recessive hereditary disease
affecting young Holstein calves. Homozygous
individuals die from extreme susceptibility to
infection, caused by an inability of leukocytes to
pass from the blood stream into infected tissue.
This inability is due to the lack of beta-2
integrin adhesion protein on the surface of the
white blood cells due to two point mutations in
the CD18 gene.

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